Best Medicine (2026)

About This Series

Best Medicine is a comedy and drama series created by Liz Tuccillo. Its leading cast includes Josh Charles, Abigail Spencer and Josh Segarra. It premiered on January 4, 2026 on FOX. TMDB lists 2 seasons and 20 episodes so far and is listed as a returning series.

Synopsis

Martin Best is a brilliant surgeon who abruptly leaves his illustrious career in Boston to become the general practitioner in a quaint East Coast fishing village where he spent summers as a child. Unfortunately, Martin's blunt and borderline rude bedside manner rubs the quirky, needy locals the wrong way, and he quickly alienates the town, even though he's all they’ve got.

Synopsis from TMDB.

Official Trailer

Official Trailer · plays from YouTube

• Josh Charles Is Doc Martin (opens YouTube)

Cast

• Josh Charles Dr. Martin Best 20 episodes
• Abigail Spencer Louisa Glasson 20 episodes
• Josh Segarra Sheriff Mark Mylow 20 episodes
• Cree Elaine Denham 20 episodes
• Annie Potts Aunt Joan 20 episodes
• Stephen Spinella Greg Garrison 9 episodes
• Jason Veasey George Brady 9 episodes
• Eliza Coupe Dr. Eden Montgomery 9 episodes
• Ben Lewis Doherty Peter Cronk 7 episodes
• Carter Shimp Al Large 4 episodes
• John DiMaggio Bert Large 4 episodes
• Clea Lewis Sally Mylow 3 episodes
• Didi Conn Geneva 3 episodes
• Alison Cimmet Irma 3 episodes
• Michael Potts Gilbert Carlisle 2 episodes
• Wendy Makkena Susan Carlisle 2 episodes
• A Alexandra Sica Harley 2 episodes
• L Leah Janae Thomas Amelia 2 episodes

Seasons

Next episode: season 2, episode 7, airs Nov 10, 2026.

• Season 12026 · 13 episodes
• Season 22026 · 7 episodes